Intraoperative radiation therapy has transformed cancer care worldwide, with studies showing up to a 30–40% reduction in local recurrence for selected cancers when high-precision radiation is delivered during surgery. In 2025, patients across India increasingly seek advanced, targeted treatment options that shorten recovery time and improve long-term outcomes. At the forefront of this progress in Karnataka is Dr. Mathangi J, Senior Consultant and In-charge of radiation oncology at Gleneagles Cancer Institute, Bangalore — a leader known for bringing global innovations to Indian cancer care.
With more than 20 years of experience, global training from premier cancer centers in Germany, Denmark, and Europe, and over 12,000 successfully treated patients, Dr. Mathangi ensures that patients receive uncompromised precision through the most advanced IORT solutions available in IORT India.
Intraoperative radiation therapy is a technique where a concentrated dose of radiation is delivered to a tumor bed during surgery. This allows radiation to target cancer cells directly while sparing surrounding healthy tissues. For patients undergoing cancer surgery — especially breast, head and neck, brain, abdomen, and pelvic cancers — IORT offers a powerful and efficient treatment boost that cannot be achieved through external radiation alone.
Because the area is exposed during surgery, oncologists like Dr. Mathangi can visualize tissues precisely, minimize radiation exposure to organs, and improve long-term disease control. This direct access is the reason why more cancer patients are now actively asking for IORT-supported surgical care.
In 2025, improvements in precision imaging, radiation physics, and intraoperative delivery systems have made IORT more accurate and safer than ever. At Gleneagles Cancer Institute, Dr. Mathangi uses evidence-based protocols and modern applicators that match the shape and size of the tumor cavity to ensure accurate dose distribution.
This is especially beneficial for cancers like breast, rectal, esophageal, bladder, prostate, lung, cervical, and head and neck cancers — all of which are cancers that may require radiation therapy as part of their overall treatment plan.
The IORT procedure follows a structured sequence during surgery. Here is a simple overview for patients:
This seamless integration eliminates the need for weeks of postoperative radiation, especially in selected cases like IORT breast cancer, where IORT may serve as either a boost or, in select patients, a single definitive radiation session.
The IORT benefits are substantial, and for many patients, they can dramatically change the treatment experience. Some of the most clinically relevant advantages include:
For Indian patients, these benefits are driving rapid adoption of IORT cancer treatment in top oncology centers.
IORT cancer treatment is commonly recommended for:
At Gleneagles Cancer Institute, patient selection is done meticulously under the guidance of Dr. Mathangi, ensuring optimal clinical outcomes.
While highly targeted, IORT side effects may still occur. Fortunately, most are mild and temporary. Commonly observed effects include:
The risk of serious complications remains low when performed by experienced specialists such as Dr. Mathangi, whose training in Denmark and Germany includes advanced IORT applications.
IORT cost India varies based on cancer type, technology used, and hospital infrastructure. In most Indian centers, IORT is considered cost-effective when compared to extended external radiation schedules. Costs typically include:
At Gleneagles Cancer Institute, each patient receives a personalized treatment plan, ensuring transparent and ethical cost structuring aligned with global best standards.
Patients seek specialists not just for technology, but for experience, outcomes, and clinical intuition. This is where Dr. Mathangi stands out:
Her precision-driven method ensures that every patient receives tailored care rooted in scientific excellence and compassion.
Patients can schedule an appointment easily by submitting their contact details via the official link: https://drmathangi.com/contact/. Her team will then reach out to confirm the appointment and guide the patient through the next steps.
Dr. Mathangi J is a leading radiation oncologist based in Bangalore, India, specializing in precision radiation therapies including IORT, SRS, SBRT, IGRT, RapidArc, and interstitial brachytherapy. She currently serves as Senior Consultant & In-charge of Radiation Oncology at Gleneagles Cancer Institute and is recognized internationally for her clinical expertise and contributions to advanced radiotherapy education.
In simple terms, intraoperative radiation therapy is a technique where a precise, high dose of radiation is delivered directly to the tumour bed during surgery instead of several weeks of external radiation sessions afterward. The goal is to sterilise any microscopic cancer cells left behind after the surgeon removes the visible tumour.
Dr. Mathangi may recommend intraoperative radiation therapy when:
Through careful pre-surgical planning, imaging, and multidisciplinary discussions, she identifies patients who are most likely to benefit from this approach while keeping safety as the top priority.
The IORT procedure is a coordinated effort between the surgical team, anaesthesiologist, and radiation oncology team led by Dr. Mathangi. Once the tumour is removed, the wound is temporarily opened so that the IORT applicator or radiation cone can be positioned exactly over the area at highest risk.
During the IORT procedure:
Throughout the process, you remain under anaesthesia, and the treatment is seamlessly integrated into your surgery, avoiding separate daily hospital visits for radiotherapy.
One of the most important IORT benefits is precision: radiation is delivered directly to the area at risk while the surgeon and radiation oncologist can see and protect surrounding organs in real time. This can reduce radiation to normal tissues compared with external radiation given from outside the body.
Other potential IORT benefits include:
Dr. Mathangi helps you weigh these advantages against other options so that the chosen plan matches your cancer type, stage, and personal priorities.
IORT cancer treatment is not a one-size-fits-all solution; it is carefully reserved for selected clinical scenarios where its benefits outweigh the risks. In modern radiation oncology, IORT is commonly considered for:
As a specialist in radiation oncology, Dr. Mathangi evaluates your imaging, pathology, and overall health to decide whether IORT should be used alone, combined with external-beam radiotherapy, or not used at all. The final plan is personalised and often discussed in a multidisciplinary tumour board to ensure you receive evidence-based, comprehensive care.
IORT breast cancer treatment is typically considered for carefully selected women undergoing breast-conserving surgery (lumpectomy). Ideal candidates often include:
During your consultation, Dr. Mathangi will review your biopsy, imaging, age, tumour biology, and general health to decide whether IORT breast cancer treatment alone is sufficient or whether it should be combined with additional external-beam radiation or systemic therapies.
Her approach balances effective cancer control with cosmetic outcomes and quality of life, explaining each step so you can make an informed decision.
Like any medical treatment, IORT can have side effects, but they are usually localised because the radiation is targeted to a small area. Common IORT side effects may include:
Less commonly, there can be wound-healing issues or changes in cosmetic appearance, especially after breast surgery. To minimise IORT side effects, Dr. Mathangi:
You will have access to her team for symptom guidance, wound care tips, and long-term monitoring to ensure any problems are detected and managed early.
The IORT cost India can vary based on several factors, including the hospital infrastructure, type of cancer, complexity of surgery, technology used, and whether IORT is combined with additional external radiation or systemic therapies.
When you consult with Dr. Mathangi and her team, they:
Transparency is a key part of her practice. You are encouraged to ask detailed questions about costs, inclusions, and potential add-on treatments so that there are no surprises during your cancer journey.
Opting for IORT India with an experienced specialist like Dr. Mathangi means you receive care that is technologically advanced yet deeply personalised. Her practice brings together:
From your first consultation to post-treatment survivorship care, her team focuses on clear communication, emotional support, and long-term follow-up. This holistic approach helps you feel informed, supported, and confident in the path you choose.
Your information is kept strictly confidential.
